Thursday, July 26, 2012

Altruistic kidney donors help many

Mass exchanges result in more kidneys for difficult-to-match recipients

Web edition : Tuesday, July 24th, 2012

When a person donates a kidney to a broad pool of potential recipients, the altruistic act can kick off a long chain of donations that leads to more transplants for hard-to-match patients, a mathematical analysis concludes.

Many people needing kidney transplants have a willing donor, but they can?t take the kidney because it?s not compatible with their blood type or immune system. Paired exchanges, where incompatible donor/recipient pairs swap kidneys with another incompatible pair, is one trick for getting kidneys into hard-to-match patients. Another trick is a donor chain: A person gives a kidney to a clearinghouse or kidney exchange, which can set off a chain of donations.

Within the kidney transplant community, there?s been an ongoing debate over whether long chains ultimately mean more transplants. ?The mathematical question was, are we really transplanting more people?? says Alvin Roth, an expert in game theory and market design at Harvard. ?The answer is yes, a lot more.?

Long chains, which can involve more than 10 transplants, can result in 30 percent more transplants than a cycle of three exchanges, Roth and his colleagues calculated. That benefit varies depending on the number of difficult-to-match patients and the size of the kidney pool. These chains especially benefit patients that are hard to match and don?t harm patients who easily find a match, the researchers report in a July National Bureau of Economic Research working paper.

Hopeful transplant recipients can be difficult to match when they are what doctors call highly sensitized: The patient builds up antibodies that will attack most foreign tissue. Roth and his colleagues collected data from kidney clearinghouses on the number of these highly sensitized patients typically found in a kidney exchange pool. Because easy-to-match pairs often don?t enter pools, hard-to-match, sensitized patients can accumulate.

The researchers then developed an algorithm that finds the greatest number of matches for a pool of a given size with a given number of sensitized patients.

?It turns out to not be an easy problem. It?s very hard computationally,? says MIT?s Itai Ashlagi, who conducted the analysis along with Roth, MIT?s David Gamarnik, and Michael Rees, a transplant surgeon at the University of Toledo and medical director of the Alliance for Paired Donation, which arranged the first non-simultaneous chain of 10 kidney transplants.

There can be a considerable gap between mathematical simulations of kidney exchanges and the real world, says transplant surgeon and biostatistician Dorry Segev of Johns Hopkins, who comes down on the side of shorter chains are better. While long chains are very appealing ? such as the 30-donor, 30-recipient chain completed late last year in 17 hospitals across the country ? there?s always the danger that a potential donor will change their mind or no longer be medically able to give up a kidney, which can disrupt the chain. ?The longer the chains are, the higher chance they will fall apart,? says Segev.?

The new paper does highlight the importance of unifying kidney exchange programs, says Segev. Creating one large pool and coordinating transplant efforts nationwide would surely mean more transplants. ?Right now, your experience depends very much on what center you work with,? he says. ?We?re still in the Wild West of kidney donation.?


Found in: Numbers and Science & Society

Source: http://www.sciencenews.org/view/generic/id/342513/title/Altruistic_kidney_donors_help_many

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Wednesday, July 25, 2012

Fresh clashes in northeast India, toll rises to 22

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Source: http://news.yahoo.com/fresh-clashes-northeast-india-toll-rises-22-075545125.html

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Monday, July 23, 2012

Pranab Mukherjee Elected India's 13th President

?Pranab Mukherjee became the 13th elected president of India on Sunday, capping a four-decade career as a central figure in Indian politics,? Jim Yardley wrote in The New York Times. Mr. Mukherjee, a member of the Indian National Congress Party which leads the coalition government in India, ?has often been described as the indispensable man in India?s coalition government,? Mr. Yardley wrote.

He most recently served as finance minister of India, before being nominated as the government?s presidential candidate.

Mr. Yardley described the post of president in India as a ?prestigious but largely ceremonial office.?

Though the prime minister is the head of the Indian government, the president holds some meaningful powers under the Constitution, including the right to grant clemency to prisoners, and is nominally the commander in chief of the armed forces. Still, the post mainly involves meeting foreign dignitaries and posing for photos in various settings.

Read the full article.

Source: http://india.blogs.nytimes.com/2012/07/23/pranab-mukherjee-elected-indias-13th-president/

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James Holmes Appears in Court, Exhibits Bizarre Behavior


James Holmes appeared in court for the first time today, and both video accounts and witness accounts confirm that the alleged Aurora, Colorado shooter exhibited extremely unusual behavior while listening to a judge charge him with first degree murder.

James Holmes in Court

As you can see, the 24-year old donned organ hair and a red jumpsuit, sitting alongside his lawyer and shifting between wide open eyes and shut eyes. At various time, it appeared as if he had fallen asleep.

Holmes remained silent for the duration of the hearing, as the judge informed this suspect that he would be held without bail and forbidden from contacting the families of his 12 victims.

Arapahoe County District Attorney Carol Chambers spoke briefly with reporters after the courtroom session and said it's unknown at the moment whether prosecutors will seek the death penalty against Holmes. His trial is expected to begin in the summer of 2013.

Source: http://www.thehollywoodgossip.com/2012/07/james-holmes-appears-in-court-exhibits-bizarre-behavior/

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LASIK Eye Treatment | Health Insider

Laser eye surgery, often called LASIK surgery, is one of the most successful treatments available to restore poor or diminishing vision. A successful laser eye surgery means saying goodbye to glasses, contacts, and looking at the world with a perpetual squint. There are several conditions for which laser surgery has been successful:? Myopia, Hyperopia, and Astigmatism.? These conditions are usually the result of a misshapen or damaged cornea.? Once a patient has healed from LASIK surgery, improved vision is immediate.

?

Before understanding how this procedure works, it is important to understand a bit about how the eye works.? The main parts of the eye responsible for vision include:

  • Cornea
  • Sclera
  • Iris
  • Lens
  • Pupil
  • Retina
  • Vitreous
  • Humor
  • Optic Nerve

?

The cornea covers the outer center of the eye. Its role is to bend, or refract, the light that enters through the pupil.? The light is directed into the iris, and continues through the lens and the vitreous. Eventually, this refracted light comes to a sharp point in the rear of the eyeball ? focused on the retina. The retina uses photoreceptor nerve cells to translate the light into electric impulses which travel down the optic nerve.

?

These electrical impulses are translated into an image by the brain.? Unfortunately, a damaged or misshapen cornea distorts the light and it can appear as more than one point on the retina.? This creates blurred and/or distorted images.

?

Laser Eye Surgery: A Solution For Myopia, Hyperopia, or Astigmatism

?

As mentioned above, a distorted cornea often causes the following conditions:

  • Nearsightedness (Myopia)
  • Farsightedness (Hyperopia)
  • Astigmatism ? a separate condition where light fails to merge to a single point on the retina.

Laser eye surgery can usually fix the above conditions. After a routine eye exam, an optometrist or ophthalmologist can confirm whether or not laser eye surgery is an option for a patient.

?

There are three situations in which laser eye surgery should not take place:

  • If a patient is younger than 18 years of age
  • A patient who is pregnant
  • A patient who is nursing

?

What Is Laser Eye Surgery?

?

Laser eye surgery amends the shape of the cornea in about 15 minutes.? There are no stitches involved.? Patients should notice visible improvement within about 24 hours.

?

The patient?s eye is completely numbed prior to the procedure and s/he will only feel a slight pressure. The doctor will create a small ?flap? using a microkeratome ? a very small oscillating blade. The flap will be gently folded back to expose the cornea.? A laser will be used to contour the cornea to the correct proportions, depending on the patient?s prescription.? After the cornea is re-contoured, the flap is gently replaced.? The eye heals so quickly that no stitches are necessary.

?

Preparation for Laser Eye Surgery

?

First, the patient will have a pre-operative exam to verify that s/he is a candidate for the procedure. It is advised that contact lenses are not be worn for at least a week prior to the pre-operative exam.? This time period is even longer for patients who wear hard contact lenses.? Patients will also have to refrain from wearing contacts prior to receiving LASIK surgery. The specific period of time will depend on the types of lenses worn.

?

Post-Op Treatment For LASIK Surgery

?

After the quick and painless procedure, patients will be prescribed anti-inflammatory drops, as well as an antibiotic, to be taken for a week after the procedure. Patients should also wear dark lenses to protect vulnerable eye tissues from bright light. The eyes should not be rubbed, in order to allow tissues to heal properly, so special goggles should be worn at night until the eyes are completely healed.

?

In just 15 minutes, LASIK surgery safely provides patients with fresh, positive, and unencumbered views.

??

Megan writes for PersonalEYES, a vision correction surgery with several locations in Sydney. Their specialties include laser eye surgery, cataracts surgery and LASIK.

Source: http://www.healthinsider.com.au/240/general-health/do-you-need-laser-eye-surgery

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Sunday, July 22, 2012

Indian upheaval bares Colombia's nagging conflict

TORIBIO, Colombia (AP) ? One of the stiffest blows in years to the prestige of Colombia's military wasn't inflicted by its leftist rebel foes and didn't claim a single soldier's life.

It was dealt by a relatively diminutive people called the Nasa who marched furiously up to the top of a 7,500-foot (2,300-meter) peak last week and forcibly dislodged a clutch of soldiers from a strategic outpost.

These verdant, craggy mountains are the Nasa's ancestral lands and the Indians say they are fed up with violent usurpers. They are demanding that the country's military and its rebel foes leave their enclave in the southwestern state of Cauca.

Yet neither side in Colombia's half-century old conflict is heeding the Nasas' wishes to leave them in peace. Their homeland lies on a key corridor that rebels and their chief funding source, cocaine, regularly transit on their way to the Pacific coast.

The government alleges that some of the 115,000 Nasa are allied with rebels of the leftist Revolutionary Armed Forces of Colombia, or FARC, which authorities say purchases the high-quality marijuana that many Indians grow.

The Indians' widely broadcast standoff with government troops has made this past week perhaps the most difficult of Juan Manuel Santos' two-year-old presidency, bringing Colombia's conflict into people's living rooms as it rarely has been in recent years and highlighting his government's inability to control large parts of the countryside. Santos even suffered the indignity of being jeered by the Nasa when he visited Toribio the previous week to announce investments in social programs.

Colombia's conflict plays out far from its sparkling cities. Its victims are its most marginalized.

"We sometimes get the impression that there's hardly any conflict at all, that it is very distant," said Jordi Raich, the International Committee of the Red Cross' country director. "But Colombia's armed conflict continues, and while it may be happening in remote areas, the humanitarian consequences are not lessened."

"Peace is distant," he added.

The conflict claims hundreds if not thousands of lives a year, mostly civilians killed in a dirty war involving right-wing death squads, rebels and the military. Yet in terms of violence, this month's upheaval in Cauca has been comparatively tame. Its damage is, instead, political.

It was clear to everyone during Santos' visit that the government had no control of the area. A FARC commander held court with reporters at a roadblock less than 3 miles (5 kilometers) away.

"This is a political defeat for the Santos government," said Jorge Restrepo, an analyst at Colombia's CERAC think tank. "It puts in question his ability to win re-election."

Santos, a 60-year-old scion of a Bogota newspaper clan, won the presidency on the coattails of Alvaro Uribe, for whom he was defense minister from 2006-2009, a time of impressive military gains against the FARC.

Santos has not said whether he will seek re-election in 2014, but his popularity has plummeted as rebel violence mounts.

The insurgents have in recent months reverted to traditional hit-and-run tactics, and stepped up attacks on infrastructure including oil facilities. On Friday, they blew up a bridge in Caqueta state in southern Colombia that was vital to oil companies.

The trigger for the Toribio upheaval came before dawn on July 6 when rebels rained crude mortars and grenades on its town center, aiming for the sandbag-shrouded police station. Such munitions rarely hit their mark, and instead tore big chunks out of the brightly colored brick homes surrounding it. Three days later, when the bombardment ended, six people were wounded and about 100 left homeless, said Toribio's mayor, Ezequiel Vitonas.

Four people were wounded in a separate grenade attack on July 8 on a Toribio medical clinic. The next day, angry Indians tried to dismantle the sandbag wall protecting the police station.

"We can't take it anymore," said the governor of the local Nasa reserve, Marcos Yule, counting about 1,000 such attacks in the past few years. The worst had come on July 9, 2011, he said, when the FARC exploded a bus bomb a block from Toribio's central plaza, killing three people.

Santos came to town two days after that anniversary, and later accused some "elements" of the Nasa of being in cahoots with the rebels, a charge that Nasa leaders deny.

Colombia's counter-narcotics police director, Gen. Luis Perez, says the FARC would be pleased to have the military out of the area to lessen the chances of having their harvested marijuana seized.

Perez estimates at least 250 acres (100 hectares) of marijuana plants grow in the Cauca. What is grown on the Nasa indigenous reserve is legally protected from destruction. At night, the hills around Toribio are pitted with lights used by cultivators to accelerate the plants' growth and potency.

As those lights went off at dawn Wednesday, hundreds of Nasa headed for the strategic hilltop, where a small group of soldiers was encamped, charged with protecting communications antennas and keeping an eye on mountain trails regularly used by the FARC.

Among the Indians were "guardians," men and women who carry staffs hewed from palm trees and decorated with brightly colored ribbons. The staffs, says Yule, are instruments of authority only and cannot be used as weapons.

In the ensuing pandemonium, several dozen Indians encircled six soldiers and forced them off the hilltop. One soldier fired a burst of shots into the air, sending reporters scurrying. But only egos were hurt.

The images, meanwhile, were published around the world.

The mayhem was strangely isolated. While those involved in the struggle kicked up dust, hundreds more Nasa peacefully rested on the grass as other solders gathered their belongings and sheepishly retreated downhill.

The next day, however, the soldiers, accompanied by riot police, were back. Firing tear gas and buckshot, they retook the hilltop. Eight Nasa were injured, none critically, said Luis Angel Penna, Toribio's assistant hospital director.

And the violence wasn't over.

Two local men were killed by gunfire over the next two days in the neighboring towns, one during a demonstration by farmers trying to eject soldiers from their village, another shot for allegedly failing to heed an order to halt at a military roadblock.

The tensions and mistrust are not new.

In May, 39-year-old coffee picker Julio Dagua was killed near Toribio by rebels who had falsely accused him of being an army informant, said his brother Edgar.

"He had been threatened for a long time," he added.

Edgar Dagua said residents won't be intimidated by either side in the conflict. "They're going to have to kill all of us."

Some of Toribio's residents earlier this month joined the more than 2 million Colombians who have been internally displaced by the country's conflict. They are living temporarily in a shelter in the nearby town of Santander de Quilichao.

One is Maria Alejandra Munoz, a garrulous, 38-year-old mother of three who earns her living washing other people's laundry by hand. "You get tired of this conflict."

Her brother, Ruben, said that "what people want most is peace for our town."

But how?

"That's difficult," said Maria Alejandra, leaning against a support in the cramped shelter. "If someone had a formula for it, they'd give it to the presidents."

___

Associated Press Writer Frank Bajak contributed to this report from Caracas, Venezuela

Source: http://news.yahoo.com/indian-upheaval-bares-colombias-nagging-conflict-071244891.html

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Saturday, July 21, 2012

Niagara Falls, NY, wants daredevil Wallenda to pay

NIAGARA FALLS, N.Y. (AP) ? The city of Niagara Falls says daredevil Nik Wallenda still owes about $25,000 for public safety costs from last month's tightrope walk across the falls, but Wallenda says the New York city has already received more than it should have.

The dispute boils down to differing interpretations of legislation the state passed to permit the June 15 stunt. The legislation requires Wallenda to pay "any and all costs associated with safety in conjunction with law enforcement or security."

Mayor Paul Dyster said Friday that entitles the city to be reimbursed the $43,000 it spent, mostly on police and fire overtime, as part of a crowd and traffic management plan. The city, which held a street festival and other activities, has been paid $17,500 so far, he said.

But Wallenda and his attorney, John Bartolomei, countered the city isn't entitled to anything because Wallenda's walk took place on New York state property and the state already has been paid. They said any expenses incurred by the adjacent city of Niagara Falls came from activities it staged on its own to try to capitalize on the spectacle and aren't Wallenda's to bear.

"Just because Neil Diamond is playing down the road doesn't mean you can throw an event and charge him security fees for the event," Wallenda, of Sarasota, Fla., said by phone. "I just think it's goofy."

Bartolomei sent a letter to the city this week saying that not only should Wallenda not have to pay the additional $25,000, he should be refunded the $17,500 already paid.

Wallenda began his walk from Niagara Falls State Park, where about 4,000 people were permitted to watch, and finished across the gorge in roomier Niagara Falls, Ontario, where an estimated 120,000 people gathered.

Wallenda paid $200,000 to New York state and $100,000 to Canada to cover their costs for the event, which was broadcast live in prime time. New York's sum included $150,000 for security, Wallenda said.

"I had an agreement with the state that was fulfilled," he said.

"I know the city's crying about its cash flow, but why come after this guy?" said Bartolomei. "This is the guy who generated tens of millions of dollars of free advertising for the city of Niagara Falls."

Wallenda called the dispute disheartening as he considers in which country he might stage a follow-up tourist attraction and show. He said that not only have Canadian officials not sought any additional money, but they've more warmly embraced him, inviting him back for appearances and the dedication of a plaque. The mayor of Niagara Falls, Ontario, is pushing to build an elevated, life-size bronze statue of Wallenda so tourists can take pictures that give the illusion they are walking the high wire with him. Mayor Jim Diodati said he sees it as a potential tourist draw.

"They just get it," Wallenda said.

Dyster, however, said his effort to recoup expenses is strictly business.

"I don't have the right as mayor of the city of Niagara Falls to gift public funds," he said. "I'm not a private businessman dealing with Nik Wallenda. ... I'm acting under legislation that gives me the opportunity and the duty to recover the costs."

Wallenda negotiated a separate agreement with Canada under a resolution approved by its Niagara Parks Commission. Diodati said he didn't expect to be fully reimbursed for the extra police and fire crews who were on duty.

"We'll spend millions of dollars marketing our destination," he said. "We saw this as, an event came to us unsolicited. We became a partner."

Source: http://news.yahoo.com/niagara-falls-ny-wants-daredevil-wallenda-pay-173029011.html

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